Scientists collaborate to assess the impact of an infection with Mycobacterium bovis on different cow breeds
Scientists from the Universidad Nacional Autónoma de México (Facultad de Medicina Veterinaria y Zootecnia,), the Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (Guadalajara Jalisco, México), Public Health England (Porton Down, Salisbury), the Department of Bacteriology (APHA Weybridge, UK), IBERS, Aberystwyth University (Aberystwyth, UK), and The Department of Pathobiology and Population Sciences, 新月直播 collaborated on a British Council funded Institutional Link Newton grant to assess the impact of an infection with Mycobacterium bovis on different cow breeds.
Mycobacterium bovis is the main causative agent of bovine tuberculosis (BTB) in cattle and it is also responsible for a proportion of human TB cases. The annual cost of BTB worldwide is estimated at US$3 billion. Zebu cattle are considered to be more resistant to some infectious diseases than Holstein-Friesian (HF) cattle, including BTB. However, epidemiological studies do not necessarily take into account usage differences of the two types of cattle breeds, being either dairy or beef. In their work, the researchers used a recently developed vaccination-and-BCG challenge model to compare the ability of naïve and vaccinated Zebu and HF cattle, housed in the same accommodation in Mexico, to control/kill mycobacteria. Whereas fewer bacteria were recovered from vaccinated HF cattle, no such trend was observed in Zebu cattle. In contrast, evaluation of antigen-specific IFNγ secretion indicated that Zebu and HF cattle differed in their response to mycobacteria. However, it became also apparent that animals of both breeds, all sourced in Mexico, were infected with environmental Mycobacteria, which impacted on the trial and showed that current European test systems may be not transferred directly to other environmental conditions.
Alcaraz新月直播怢ópez, O A and Flores新月直播怴illalva, S and Cortéz新月直播怘ernández, O and Vigueras新月直播怣eneses, G and Carrisoza新月直播怳rbina, J and Benítez新月直播怗uzmán, A and Esquivel新月直播怱olís, H and Werling, D and Salguero Bodes, F J and Vordemeier, M and Villarreal新月直播怰amos, B and Gutiérrez新月直播怭abello, J A (2020)
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Transboundary and Emerging Diseases. ISSN 1865-1674
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